He was born in
Nancy, Lorraine (now in
France), the oldest surviving son of
Leopold Joseph, duke of Lorraine, and his wife
Elizabeth Charlotte, daughter of
Philippe I, duc d'Orléans and
Elizabeth Charlotte, Princess Palatine. He was connected with the
Habsburgs through his grandmother Eleanore, daughter of Emperor
Ferdinand III, and wife of
Charles Leopold of Lorraine, his grandfather.
Emperor
Charles VI favored the family, who, besides being his cousins, had served the house of
Austria with distinction. He had designed to marry his daughter
Maria Theresa to Francis' older brother Clement. On Clement's death, Charles adopted the younger brother as his future son-in-law. Francis was brought up in
Vienna with Maria Theresa on the understanding that they were to be married, and a real affection arose between them.
At the age of 15, when he was brought to
Vienna, he was established in the
Silesian Duchy of Cieszyn, which had been mediatized and granted to his father by the emperor in 1722. He succeeded his father as
Duke of Lorraine in
1729, but the emperor, at the end of the
War of the Polish Succession, agreed to compensate the French candidate
Stanislaus Leszczynski for the loss of his crown in
1735 and persuaded Francis to exchange Lorraine for the
Grand Duchy of Tuscany.