In Mino, Saitō Yoshitatsu died suddenly of illness in 1561, and was succeeded by his son,
Saitō Tatsuoki. Tatsuoki, however, was young and much less effective as a ruler and military strategist compared to his father and grandfather. Taking advantage of this situation, Nobunaga moved his base to Komaki Castle and started his campaign in Mino. By convincing Saitō retainers to abandon their incompetent and foolish master, Nobunaga weakened the Saitō clan significantly, eventually mounting a final attack in 1567. Nobunaga captured
Inabayama Castle and sent Saitō Tatsuoki into exile.
After taking possesion of the castle, Nobunaga changed the name of both the
castle and the surrounding town to
Gifu. Remains of Nobunaga's residence in Gifu can be found today in
Gifu Park. Naming it after the legendary Mount Qi (岐山
Qi in
Standard Mandarin) in
China, on which the
Zhou dynasty started, Nobunaga revealed his ambition to conquer the whole of Japan. He also started using a new personal
seal that read
Tenka Fubu (天下布武), which means "Spread the militarism over the whole land", or literally "... under the sky" (see
all under heaven). In 1564, Nobunaga had his sister,
Oichi, marry
Azai Nagamasa, a daimyo in northern
Ōmi Province. This would later help pave the way to
Kyoto.
In 1568,
Ashikaga Yoshiaki went to Gifu to ask Nobunaga to start a campaign toward Kyoto. Yoshiaki was the brother of the murdered thirteenth
shogun of the
Ashikaga shogunate, Yoshiteru, and wanted revenge against the killers who had already set up a puppet shogun,
Ashikaga Yoshihide. Nobunaga agreed to install Yoshiaki as the new shogun and, grasping the opportunity to enter Kyoto, started his campaign. An obstacle in southern Ōmi Province, however, was the
Rokkaku clan. Led by Rokkaku Yoshikata, the clan refused to recognize Yoshiaki as shogun and was ready to go to war. In response, Nobunaga launched a rapid attack, driving the Rokkaku clan out of their castles.
Within a short amount of time, Nobunaga had reached Kyoto and driven the
Miyoshi clan out of the city. Yoshiaki was made the 15th shogun of the Ashikaga shogunate. Nobunaga refused the post of
Kanrei and eventually began to restrict the powers of the shogun, making it clear that he intended to use him as a puppet to justify his future conquests. Yoshiaki, however, was not pleased about being a puppet and secretly corresponded with various daimyo, forging an anti-Nobunaga alliance.
The Asakura clan was particularly disdainful of the Oda clan's increasing power because, historically, the Oda clan had been subordinate to the Asakura clan. Furthermore,
Asakura Yoshikage had also protected Ashikaga Yoshiaki, but had not been willing to march toward Kyoto. Thus, the Asakura clan also despised Nobunaga the most for his success.
When Nobunaga launched a campaign into the Asakura clan's domain, Azai Nagamasa, to whom Oichi was married, broke the alliance with Oda to honor the Azai-Asakura alliance which had lasted for generations. With the help of
Ikko rebels, the anti-Nobunaga alliance sprang into full force, taking a heavy toll on the Oda clan. At the
Battle of Anegawa, Tokugawa Ieyasu joined forces with Nobunaga and defeated the combined forces of the Asakura and Azai clans.
Nobunaga waged war even against Buddhists when they did not obey him. The
Enryaku-ji monastery on
Mt. Hiei, with its
sōhei (warrior monks) of the
Tendai school, was a particular thorn in Nobunaga's side, residing as it did so close to his residence in Kyoto. Nobunaga attacked Enryaku-ji and burnt it to the ground in 1571, even though it had been admired as a significant cultural symbol at the time, and killed between 20,000 and 30,000 men, women and children in the process.
Through the years, Nobunaga was able to further consolidate his position and conquer his enemies through brutality. In
Nagashima, for example, Nobunaga suffered tremendous losses to the Ikko resistance, including the death of a couple of his brothers. When Nobunaga finally surrounded the enemy complex, he set fire to it, again killing tens of thousands of non-combatants, mostly women and children.
One of the strongest rulers in the anti-Nobunaga alliance was
Takeda Shingen, in spite of his generally peaceful relationship and a nominal alliance with the Oda clan. In 1572, at the urgings of the shogun, Shingen decided to make a drive for the capital. Tied down on the Western front, Nobunaga sent lackluster aid to Ieyasu, who suffered defeat at the
Battle of Mikatagahara in 1572. However, after the battle, the Takeda forces retreated after Shingen died of illness in 1573. This was a relief for Nobunaga because he could now focus on Yoshiaki, who had openly declared hostility more than once, despite the imperial court's intervention. Nobunaga was able to defeat Yoshiaki's weak forces and send him into exile, bringing the
Ashikaga shogunate to an end in the same year.
Also in 1573, Nobunaga successfully destroyed the Asakura and Azai clans, leading Azai Nagamasa to send Oichi back to Nobunaga and commit suicide. With Nagashima's destruction in 1574, the only threat to Nobunaga was the Takeda clan, now led by
Takeda Katsuyori.
At the decisive
Battle of Nagashino, the combined forces of Nobunaga and Tokugawa Ieyasu devastated the Takeda clan with the strategic use of
arquebuses. Nobunaga compensated for the arquebus' slow reloading time by arranging the arquebusiers in three lines. After each line fired, it would duck and reload as the next line fired. The bullets were able to pierce the Takeda cavalry armor, causing chaos among the Takeda cavalry, who were pushed back and killed by incoming fire. From there, Nobunaga continued his expansion, sending
Shibata Katsuie and
Maeda Toshiie to the north and
Akechi Mitsuhide to
Tamba province.
The Oda clan's siege of
Ishiyama Hongan-ji in
Osaka made little progress, but the Mori clan of the
Chūgoku region broke the naval blockade and started sending supplies into the strongly-fortified complex by sea. As a result, in 1577,
Hashiba Hideyoshi was ordered to expand west to confront the Mori clan.
However,
Uesugi Kenshin, said to be the greatest general of his time since the demise of
Takeda Shingen, took part in the second anti-Nobunaga alliance. Following his conquest of neighboring forces, the two sides clashed during the Battle of Tedorigawa which resulted in a decisive Uesugi victory. It was around this time that Uesugi forces began preparations to march on Kyoto.
Due to his defeat, Oda Nobunaga harbored clear fears of Uesugi and, according to one account, told the messenger that brought news of Uesugi Kenshin's orders of general mobilization that, if Kenshin did in fact lead his armies to the capital, he would have no choice but to surrender and cede his eastern domains in the hopes of being granted mercy. Uesugi Kenshin, however, died from what was possibly a stroke before moving his armies.
Nobunaga forced the Ishiyama Hongan-ji to surrender in 1580 and destroyed the Takeda clan in 1582. Nobunaga's administration was at its height of power and he was about to launch invasions into
Echigo Province and
Shikoku.