Panabaker followed her initial appearances in commercials with roles in television, including a part in the series,
The Guardian (for which she won a
Young Artist Award), as well as other
television series including
Malcolm in the Middle,
Law & Order: Special Victims Unit,
Summerland, and the
Disney Channel Original Movie Stuck in the Suburbs. She has also appeared in the
Lifetime Television productions
Sex and the Single Mom and
Mom at Sixteen, as well as the well-reviewed
miniseries Empire Falls. In addition, Panabaker also appeared in stage productions with roles in
musical theater, including
West Side Story,
Pippin,
Once Upon A Time, and
Beauty Lou and the Country Beast.
In
2005, Panabaker co-starred in two widely released theatrical films,
Sky High and the remake of the film
Yours, Mine and Ours. Her next role will be in the film
Home of the Giants, opposite
Ryan Merriman and
Haley Joel Osment. She will also have a supporting role in the independent film
Mr. Brooks. In the Disney Channel Original Movie
Read It and Weep, she plays "Is", an alternate version of Jamie, who is played by her sister Kay Panabaker.
Panabaker was added to the cast of the
CBS television drama
pilot Shark, as "Julie Stark", the main character's daughter and now has a regular role in the series.
Panabaker was originally going to star as the lead character in the
horror/thriller film
Solstice, but dropped out due to scheduling complications. She was replaced by
Elisabeth Harnois.
She is being looked at for the role of Bella Swan in the upcoming movie Twilight.