Blake's musical training began when he was just four or five years old. While out shopping with his mother, he wandered into a music store, climbed on the bench of an organ, and started "foolin’" around. When his mother found him, the store manager said to her: "The child is a genius! It would be criminal to deprive him of the chance to make use of such a sublime, God-given talent." The Blakes purchased a pump organ for
US$75.00 making payments of 25 cents a week. When Blake was seven, he received music lessons from their neighbor, Margaret Marshall, an organist from the Methodist church. At age fifteen, without knowledge of his parents, he played piano at Aggie Shelton’s Baltimore bordello.
Blake said he first composed the melody to the "Charleston Rag" in 1899, which would have made him 12 years old, but he did not commit it to paper until 1915, when he learned to write in musical notation.
In 1912, Blake began playing in
vaudeville with
Jimmy Europe's "Society Orchestra" which accompanied
Vernon and Irene Castle's ballroom dance act. The band played
ragtime music which was still quite popular at the time. Shortly after
World War I, Blake joined forces with performer
Noble Sissle to form a vaudeville music duo, the "Dixie Duo." After vaudeville, the pair began work on a musical revue,
Shuffle Along, which incorporated many songs they had written. When it premiered in 1921,
Shuffle Along became the first hit musical on
Broadway written by and about African-Americans. The musical also introduced such hit songs as "I'm Just Wild About Harry" and "Love Will Find a Way."
In 1923, Blake made three films for
Lee DeForest in DeForest's
Phonofilm sound-on-film process. They were
Noble Sissle and Eubie Blake featuring their song "Affectionate Dan",
Sissle and Blake Sing Snappy Songs featuring "Sons of Old Black Joe" and "My Swanee Home", and
Eubie Blake Plays His Fantasy on Swanee River featuring Blake performing his "Fantasy on Swanee River". These films are in the
Library of Congress collection.