In early January, she reached her first quarterfinal of the season in
Hobart, defeating on her way
Tatiana Perebiynis and
Dinara Safina before losing to
Iveta Benešová. Vaidišová picked up her first
Grand Slam singles victory in her
Australian Open début by reaching the third round with victories against
Maria Vento-Kabchi and
Jelena Kostanić, falling to top seed
Lindsay Davenport. Following the tournament, she jumped in the ranking from No. 70 to No. 57.
In April, at the
Family Circle Cup, she made her top 50 début at No.47 and reached her first career Tier I quarterfinals at
Charleston, saving two match points in first round victory against qualifier
Shahar Pe'er. She then posted her first top 10 victory over defending
French Open champion
Anastasia Myskina before also defeating
Shinobu Asagoe in three sets. Vaidišová then fell to
Patty Schnyder in the quarterfinals, making her top 40 début at No. 34 on
April 18.
In May, Vaidišová reached her first Tier III final in
Istanbul, losing to top seed
Venus Williams in the championship match. She made her début at
Roland Garros, defeating
Lucie Šafářová in the first round before falling in No. 22 seed
Francesca Schiavone in the next round.
In August, she reached the quarterfinals at
Toronto, defeating on her way lucky loser
Shenay Perry, Nathalie Dechy and
Hana Šromová before losing to
Justine Henin-Hardenne. Her ranking continued to improve, jumping from No. 32 to No. 27 on
August 22.
In September, at the
2005 US Open, she reached the fourth round for the first time at a
Grand Slam event, defeating
Květa Peschke, Zheng Jie and qualifier
Ivana Lisjak before losing to
Nadia Petrova.
Her ranking improved following the
US Open, going from No. 28 to a career-high No. 23 on
September 12. She captured her first title of
2005 (and third of career) at
Seoul, defeating top seed
Jelena Janković in the final without dropping a set during the week. She moved to career-best No. 21 at the start of October.
In that month, she captured her second straight Tour singles title as at
Tokyo (
Japan Open), winning when
Tatiana Golovin retired while trailing 7-6(4) 3-2 due to a left achilles tendonitis in the final. On
October 10, she made her top 20 début at No. 18 and extended her winning streak to 15 matches by winning her third consecutive Tour singles title and fifth of her career; she beat
Conchita Martínez and
Gisela Dulko en route to final, then overcame a 4-2 third-set deficit to defeat
Nadia Petrova for the first time, 6-1 6-7(5) 7-5, in the final.
With the
Seoul, Tokyo and
Bangkok titles, Nicole Vaidišová became the first player since
Lindsay Davenport in
2004 to win three titles in three weeks, and also became the sixth woman to win five Tour singles titles before her 17th birthday (after
Tracy Austin, Andrea Jaeger, Monica Seles, Jennifer Capriati and
Martina Hingis). On
October 17, she improved her ranking from No. 18 to No. 17, another career-high.