Queen Plaisance of Cyprus, born Plaisance of Antioch or Plaisance de Poitiers (1235/1236 or c. 1235 – September 27/22, 1261) was a daughter of Bohemund V of Antioch and his second wife, the Italian noblewoman Lucienne dei Conti di Segni, kinswoman of Pope Innocent III. She became Queen consort and Queen regent of the Kingdom of Cyprus and acting Regent of the Kingdom of Jerusalem between 1236 and 1261.

She was firstly married in 1250 to the Henry the Fat of Cyprus, who died in 1253. Their son, the child Hugh II, became king with Plaisance as regent, and it was determined that Hugh did not (yet) have a legal claim to the kingdom of Jerusalem, which was at the time nominally ruled by the child Conradin. Nevertheless, in 1258, Plaisance's brother Bohemund VI of Antioch brought Hugh and Plaisance to Acre and demanded that they be recognized as king and regent, respectively. John of Ibelin (count of Jaffa), the Knights Templar, and the Teutonic Knights agreed with this, against the opposition of the Knights Hospitaller and various jurists who still wished to recognize Conradin as king, even though he was not present in the kingdom. In any case, the position of regent belonged by birthright to the underage Hugh, who was Conradin's immediate heir and hereditarily the next king if Conradin failed to have his own progeny.

Plaisance, supported by a majority of the nobles, was accepted as acting regent and then appointed her former father-in-law John of Ibelin (lord of Arsuf) to rule as bailiff in her place; he had already been bailiff before her arrival and both Bohemund and John of Jaffa had hoped the presence of Plaisance and Hugh would eliminate the need for another bailiff. The dispute continued and Pope Alexander IV sent the Genoese to attempt to settle it; John of Jaffa convinced Bohemund and Plaisance to unite Jerusalem, Antioch, and Tripoli against them. In 1260 the high churchman (a future pope) Jacques Pantaleon arrived to take up the vacant patriarchate, hoping to solve the crisis. Around this time Plaisance apparently became John of Jaffa's mistress, against the new patriarch's wishes.

Before December 7, 1254, as a widow, Plaisance married Balian d'Ibelin, Lord of Arsuf, son of Jean d'Ibelin, Lord of Arsuf, but they divorced and had the marriage annulled in 1258. Plaisance died in 1261 and the regency passed to her sister-in-law Isabella of Lusignan, who was married to Plaisance's brother and who was the sister of Plaisance's late husband.

She died at Cyprus and was buried there.