After the Canadian wish-fulfillment TV series
Thrill of a Lifetime arranged for her to pose for
Hugh Hefner's Playboy, she gained fame as the
Playmate of the Month for the November 1981 issue (photographed by
Richard Fegley) and eventually the
Playmate of the Year for
1982. She was briefly involved with
Hugh Hefner at that time. Since then, Tweed has primarily acted in TV series such as the
HBO comedy
1st and Ten, the prime-time
soap opera Falcon Crest and guest appearances on
Frasier, as well as
B movies. Tweed also appeared in an episode of
The Dukes of Hazzard in the seventh and final season. In 1985, she landed a role on
Days of our Lives as Savannah Wilder, a character who was working under Victor Kiriakis and through whom Steve "Patch" Johnson was introduced. She remained with the show until 1987.
Her first major theatrical film appearance was in the teen
sex comedy Hot Dog... the Movie in 1984. Since then, Tweed has appeared in over 60 films, including
Detroit Rock City, produced by Gene Simmons in 1999. She is one of the best known actresses of mainstream
erotica, and she is identified with the genre of the erotic thriller, a point she makes in her autobiography, most notably her movies
The Surrogate and
Night Eyes 2 and
3. She occasionally acts with her younger sister,
Tracy Tweed, and has also appeared in
Playboy photo spreads.
In 2006 Tweed authored an autobiography,
Kiss and Tell, published by Phoenix Press.