Seriously ill, and fearing his own death,
King Edward VI arranged the marriage Suffolk's daughter Jane to to Northumberland's son,
Lord Guildford Dudley, on 21 May 1553. Edward later altered his will to make Jane his designated successor. Edward died on 6 July 1553, and three days later Suffolk, Northumberland, and other members of the Privy Council proclaimed Jane queen. This proclamation failed, with a large-scale rallying of forces in the country to Henry VIII's eldest daughter,
Mary I.
By his wife's friendship with the new Queen Mary, Grey and his daughter and son-in-law temporarily avoided execution. However, Mary had Henry Grey beheaded on
February 23, 1554, after his conviction for
high treason for his part in Sir
Thomas Wyatt's attempt (January – February 1554) to overthrow her after she announced her intention to marry
Philip II of Spain.