Mayer had two daughters from his first marriage to Margaret Shenberg. The eldest,
Edith (Edie) Mayer, (b. August 14, 1905 - d.1987), from whom he would later become estranged and whom he would disinherit, married producer
William Goetz (who became President of
Universal Pictures). The younger, Irene Gladys Mayer, married producer
David O. Selznick. Irene Mayer Selznick later wrote in her autobiograpy, "A Private View", about having to wait to marry her betrothed, David Selznick, until Edie, the older sister, was married, in accordance with her family's views on propriety. Irene, David and LB Mayer had a fight about the date of Irene and David's wedding being too close after Edie's. David Selznick protested, saying he had waited long enough while Edie was courted and planned her wedding, and that his schedule at
Paramount Pictures, for whom he then worked, decreed he must get married when he and Irene wished, regardless of LB's protestations.
Active in Republican Party politics, Mayer served as the vice chairman of the
Republican Party of
California from
1931 to
1932 and as its state chairman between
1932 and
1933. He and Thalberg played a role in attacking muckraker and reformist
Upton Sinclair's 1934 California gubernatorial bid.