Safina won her debut tournament in 2007, in Gold Coast, Australia, defeating
Shahar Peer 4-6, 7-6(1), 6-1 in the semifinal and Martina Hingis 6-3 3-6 7-5 in the final. Following the 5-0 start to the year, she lost her sixth match of the year to
Nicole Pratt 4-6, 6-3, 6-2 in the Sydney tournament. Safina would then finish her Australian season at the third round of the Australian Open, losing to
Li Na 6-2 6-2.
Safina reached the quarterfinals at her next two tournaments in Paris and Antwerp, losing to the eventual champions at both—
Nadia Petrova in Paris and
Amélie Mauresmo in Antwerp.
Safina lost in the third round of her first
Tier I event of the year in Indian Wells to Marion Bartoli 6-4, 6-3, and lost in the fourth round at the next Tier I event in Miami to Petrova again 3-6, 6-2, 6-4.
Safina reached her fourth quarterfinal of the year at her first clay event in Amelia Island, Florida, losing to Petrova for the third time in 2007. And at her third Tier I event in Charleston, South Carolina, she would reach her second final of the year, with retirements by
Tatiana Golovin and
Vera Zvonareva in the quarterfinal and semifinal, losing to
Jelena Janković 6-2, 6-2. Safina's consistent results on clay continued in Berlin and Rome, reaching the quarterfinals at both events. At the French Open, she lost to Serena Williams 6-2, 6-3 in the fourth round.
Safina lost a three-set thriller to Janković in the semifinal of the
Ordina Open in s-'Hertogenbosch 6-3, 3-6, 7-6(6), having had a match point in the tiebreaker. Following that loss, she was upset by
Akiko Morigami in the second round of Wimbledon and lost in the second round of both the
Acura Classic and
East West Bank Classic, to
Sania Mirza and
Kateryna Bondarenko respectively.
Safina won the women's double title at the
2007 U.S. Open with her partner
Nathalie Dechy 6-4, 6-2. Dechy was the defending champion who had beat Safina in the previous final to win the 2006 title.