Simon made her screen debut in
Le Chanteur inconnu (
The Unknown Singer, 1931), and quickly established herself as one of the country's most successful film actresses. After seeing her in the 1934 film
Lac Aux Dames (USA title:
Ladies' Lake),
Darryl F. Zanuck brought her to
Hollywood in 1936 with a widespread publicity campaign.
However her films for
20th Century Fox were only moderately successful. Among others, she was cast in the
Janet Gaynor role in a
remake of the beloved silent classic
Seventh Heaven, which co-starred
James Stewart and flopped. She also appeared as an eager child/woman in
Ladies in Love, which starred Gaynor,
Constance Bennett, and
Loretta Young, a heavyweight lineup in which Simon's role left her little chance to compete effectively. Simon returned, dissatisfied, to France. There she appeared in the film
La Bête Humaine (
The Human Beast) in 1938.
With the outbreak of
World War II she returned to Hollywood and
RKO Studios where she achieved her greatest successes in English language cinema with
The Devil and Daniel Webster (1941), and the
horror films
Cat People (1942) and
The Curse of the Cat People (1944).
These films, however, did not lead to greater success and she languished in mediocre films until the end of the war.
She returned to France to act, and appeared in
La Ronde (
Roundabout, 1950). Her film roles were few after this and she made her final film appearance in 1973.
She died in
Paris, France on
22 February, 2005, aged 94, from natural causes. The
BBC mistakenly reported her age as 93, by using the wrong year of birth (1911). A few days later, French Minister of Culture
Renaud Donnedieu de Vabres issued a statement in which he extolled Simon's "charm, her irresistible smile. . . With Simone Simon's passing, we have lost one of the most seductive and most brilliant stars of the French cinema of the first half of the 20th century."
Simon never married but reportedly had numerous intimate relationships with fellow actors or musicians, among others. Her maid revealed that she gave a gold key to her boudoir to any man she was interested in, including
George Gershwin.