In
1851, Helmholtz revolutionized the field of ophthalmology with the invention of the
ophthalmoscope; an instrument used to examine the inside of the human eye. This made him world famous overnight. Helmholtz's interests at that time were increasingly focused on the physiology of the senses. His main publication, entitled
Handbuch der Physiologischen Optik (
Handbook of Physiological Optics), provided empirical theories on spatial vision,
color vision, and
motion perception, and became the fundamental reference work in his field during the second half of the nineteenth century. His theory of
accommodation went unchallenged until the final decade of the 20th century.
Helmholtz continued to work for several decades on several editions of the handbook, frequently updating his work because of his dispute with
Ewald Hering who held opposite views on spatial and color vision. This dispute divided the discipline of physiology during the second half of the 1800s.