In 1981 Pfeiffer married
Thirtysomething actor
Peter Horton, but they divorced in 1988 at the height of her career. She has been romantically linked with actors
Val Kilmer, John Malkovich, Michael Keaton, and
Fisher Stevens. In 1993 Pfeiffer married writer-producer
David E. Kelley (
Ally McBeal,
The Practice,
Boston Public, and
Boston Legal).
Earlier that year, before meeting Kelley, Pfeiffer adopted a daughter, Claudia Rose, who was then adopted by Kelley following their marriage. The adopted baby was the daughter of a African-American nurse living in New York, who already had four children. At the time of the adoption, there were rumours that money was exchanged for the baby, but Michelle has vigorously denied these claims stating that the adoption was private. On
August 5, 1994 Pfeiffer gave birth to a son, John Henry.
In an August 2006
In Style interview (her first in many years), Pfeiffer discussed her return to making movies, stating that she is "a better mother if I also work... It empowers them [her children] without me hovering, making everyone feel inadequate". Pfeiffer discussed
plastic surgery, stating that she hopes she is "courageous enough to age gracefully". Pfeiffer also referred to her beauty as a "curse", as she believes that it often stunted her ability to get serious roles and eclipsed her acting ability.