In October
1660, shortly after the Restoration's success, Sir Anthony was on the commission that controversially tried the
Regicides (those who had participated in the trial and execution of Charles I). The commission eventually found ten surviving members guilty, and another four were posthumously convicted (their bodies were exhumed and hanged publicly). One year later, he was created
Baron Ashley, of Wimborne St Giles in the County of Dorset, and appointed
Chancellor of the Exchequer.
In that position, Lord Ashley served on the
Clarendon Ministry as one of its less prominent members; he frequently quarrelled with the head of government,
Lord Clarendon, especially upon matters of religious toleration (which Ashley supported but Clarendon opposed). In 1663, Ashley was one of eight Lords Proprietors given title to a huge tract of land in
North America, which eventually became the
Province of Carolina. Ashley probably collaborated with John Locke to write the
Fundamental Constitutions of Carolina. Both the
Ashley River and the
Cooper River and the
Ashley Cooper Waterfall in South Carolina and Australia were named after Lord Ashley.
In 1666, he met
John Locke. Cooper had come to Oxford seeking treatment for a liver infection. Cooper was impressed with Locke and persuaded him to become part of his retinue.
Locke had been looking for a career and in 1667 moved into Shaftesbury's home at Exeter House in London, ostensibly as the household physician.
Shaftesbury's liver infection became life-threatening. Locke coordinated the advice of several physicians and was probably instrumental in persuading Shaftesbury to undergo an operation (then life-threatening itself) to remove the cyst. Shaftesbury survived and prospered, crediting Locke with saving his life.
After the fall of Lord Clarendon in
1667, Lord Ashley became a prominent member of the
Cabal, in which he formed the second "A". Ashley became
Lord Chancellor in
1672, and was created
Earl of Shaftesbury and
Baron Cooper, of Pawlett in the County of Somerset. He was also appointed
First Lord of Trade. He served as Chancellor for one year, but remained First Lord of Trade until
1676.
Due to his intriguing with the
Duke of Monmouth against the succession of the Catholic
Duke of York, Shaftesbury fell from favour, and became a leader of the radical
Whigs. In
1681, Shaftesbury was charged with high treason, but the charges were later dismissed. Nonetheless, he fled to the
Netherlands, where he died two years later.