On
January 14,
2000, a routine check-up revealed that an artery in Letterman's heart was severely constricted. He was rushed to emergency surgery to receive a
quintuple bypass.
During the initial weeks of his recovery, friends of Letterman introduced reruns of the
Late Show, including
Drew Barrymore,
Ray Romano,
Robin Williams,
Megan Mullally,
Bill Murray,
Regis Philbin,
Charles Grodin,
Nathan Lane,
Julia Roberts,
Bruce Willis,
Jerry Seinfeld,
Martin Short,
Danny DeVito,
Steve Martin and
Sarah Jessica Parker.
Subsequently, while still recovering from surgery, Letterman revived the late night tradition that had virtually disappeared on network television during the 1990s of 'guest hosts' by allowing
Bill Cosby,
Kathie Lee Gifford (recommended by Regis, who was asked first but had no time in his schedule),
Dana Carvey,
Janeane Garofalo, and others to host new episodes of
The Late Show. Cosby, the show's first guest host, refused to sit at Letterman's desk out of respect, using the couch instead; Garofalo followed suit, utilizing a set of grade-school desks instead.
Upon his return to the show on
February 21,
2000, a visibly thinner and weakened Letterman brought all of the doctors and nurses on stage who had participated in his surgery and recovery (with extra teasing of a nurse who had given him bed baths -- "This woman has seen me naked!"), including Dr. O. Wayne Isom and physician
Louis J. Aronne, who frequently appears on the show. In an unusual show of emotion, Letterman was nearly in tears as he thanked the health care team with the words "These are the people who
saved my life!" The episode earned an
Emmy nomination. For a number of episodes, Letterman continued to crack jokes about his bypass, including saying " 'Bypass surgery - it's when doctors create new blood flow to your heart. A bypass is what happened to me when I didn't get The Tonight Show! It's a whole different thing.'." In a later running gag he lobbied his home state of Indiana to rename the freeway circling Indianapolis (I-465) "The David Letterman Bypass."
Additionally, Letterman invited the band
Foo Fighters to play "
Everlong", introducing them as "my favorite band, playing my favorite song". During a later Foo Fighters appearance, Letterman said that the Foo Fighters had been in the middle of a South American tour which they cancelled to come play on his comeback episode.
Letterman again handed over the reins of the show to several guest hosts (including
Bill Cosby,
Brad Garrett,
Elvis Costello,
John McEnroe,
Vince Vaughn,
Will Ferrell,
Bonnie Hunt,
Luke Wilson and bandleader
Paul Shaffer) in February 2003, when he was diagnosed with a severe case of
shingles. Later that year, Letterman made regular use of guest hosts, including
Tom Arnold and
Kelsey Grammer, for new shows broadcast on Fridays. In March 2007,
Adam Sandler served as a guest host while Letterman was ill with a stomach virus.