Patricia T. Arquette (born April 8, 1968) is an Emmy Award-winning and Golden Globe Award-nominated American actress.

Arquette was born in Chicago, Illinois and was raised in Virginia and California, the daughter of Mardi Olivia (née Nowak), an actress, poet, theater operator, activist, acting teacher and therapist, and Lewis Arquette, an actor. Arquette's paternal grandfather was comedian Cliff Arquette. Arquette's mother was Jewish, the daughter of a Holocaust refugee from Poland, and her father was a convert to Islam and a descendant of explorer Meriwether Lewis. Arquette's siblings are actors Rosanna, Alexis, Richmond and David Arquette. Arquette is also the sister-in-law of Courteney Cox, who is married to her brother David.

At the age of eighteen she got her start in show business in 1986's Pretty Smart. A year later, she gained attention for her starring role in A Nightmare on Elm Street 3: Dream Warriors, playing Kristen Parker. In 1993, she starred in Tony Scott's ultra-violent True Romance, which put Arquette on the map, so to speak. Soon after, her career took off, and she has since appeared in such critically acclaimed movies as Beyond Rangoon, Ethan Frome, Lost Highway, Stigmata, Bringing Out The Dead, Human Nature, Disney's Holes, and Flirting with Disaster. In January, 2005 she began starring in her first television series, NBC's Medium. Now in its 3rd season, the success of Medium has made Arquette a household name. She won a CableACE Award in 1991 for her portrayal of a deaf epileptic in Wildflower. She won an Emmy Award for Outstanding Lead Actress in 2005 for her role as the psychic Allison DuBois on NBC's Medium. In 2006, she was nominated for a SAG award and Golden Globe Award for her role on Medium. In 2007, she was again nominated for a Golden Globe Award for Medium.

On May 7, 2007, NBC renewed Medium for a fourth season.

In April 1995, Arquette married Nicolas Cage (whom she would later co-star with in Bringing Out the Dead in 1999). They separated after nine months, but acted as a couple in public until Cage filed for divorce in February 2000. The divorce petition was withdrawn, but Arquette filed again in November 2000.

She and actor Thomas Jane became engaged in 2002 and married on June 25, 2006 at the Palazzo Contarini in Venice, Italy. They have a daughter, Harlow Olivia Calliope, born on February 20, 2003. Arquette also has a son, Enzo (b. 1989), from her previous relationship with musician Paul Rossi.

In 1997, after her mother died of breast cancer, Arquette worked to raise awareness about the disease. She has run in the annual Race for the Cure, and in 1999 was the spokesperson for Lee National Denim Day, which raises millions of dollars for breast cancer research and education.

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